Bioinformatics/Pharmacology 618 – Topics in Signaling Therapeutics

Instructors: Lee and States

TuTH 1-3

2 credits

5 weeks consisting of two 2-hr sessions/week.

This course is designed to link state-of-the-art cancer therapeutics to fundamentals in signal transduction, cancer genetics, systems biology and bioinformatics.  Topics to be covered in Winter 2006 include concepts of genetic and epigenetic factors in cancer, cancer modeling and bioinformatics, tyrosine kinase therapeutics in hematological malignancies and solid tumors (Gleevec/STI571 and beyond), anti-angiogenic agents, proteasome inhibitors, DNA-histone modifying agents.  The course will consist of a mixture of didactic lectures and student presentations.  Evaluation will be based on oral presentation and NRSA-style proposal writing. Prerequisites: two of the following: Biochemistry 550, Cell and Developmental Biology 530 and Human Genetics 541 (or permission of the instructor).