Human Genetics 541
Molecular Genetics

A combination of classic and current papers in molecular genetics will be selected to accompnay the lecture material (1-2 papers per lecture). The foundations of modern genetics will launch the course, including both the fundementals and current research methods for analysis of gene structure and gene expression. The gene expression component will include positive and negative regulation of transcription and mRNA splicing and turnover. The basics of DNA recombination, repair, and transposition will be covered in relationship to cancer, evolution, and mutagenesis. Strategies for developmental regulation will be presented. Parallels between prokaryotes and eukaryotes will be drawn, and comparisons will be made between the temporal and spatial control of gene expression in vertebrates and invertebrates. Genetic engineering topics will include gene targeting and transgenesis, with applications to understanding tissue specific control of gene expression. The course will include discussion of the Genome Project, identification of disease genes and an introduction to the medical application of molecular genetics including gene therapy.

Credits: 3

Course Homepage: http://www.hg.med.umich.edu/education/COURSES/HG541/HG541syllabus%2005-%2006.htm